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The M5 followed by the A30 takes you all the way to Penzance.
The nearest train station is Penzance; pick-ups can be arranged or you can take a taxi from the rank at the station or it is a short walk along the sea front.. First Great Western operates high-speed trains from London Paddington, South Wales and the Cotswolds to Penzance, as well as sleeper services from Paddington that let you wake up in the morning with a coffee and a view across Mount’s Bay. This is how the smart money travels – it’s very exciting and romantic way to arrive in Cornwall. Cross Country Trains runs some services into Cornwall from the Midlands, the North and Scotland.
The nearest airport is Newquay or Exeter.
The nearest continental ferry is Plymouth with links from France and Spain. Penzance is also the ferry port for the Isles of Scilly